Metabolic Intervention Restores Fertility and Sperm Health in Non-Obese Diabetic Rats

ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Reproduction

Volume 16 – 2025 |
doi: 10.3389/fendo.2025.1558769

Provisionally accepted

¹ Acıbadem University, Istanbul, Türkiye
² University of Florence, Florence, Tuscany, Italy
³ Faculty of Medicine, Mersin University, Yenişehir, Mersin, Türkiye

The final, formatted version of the article will be published soon.

Background: In people with diabetes, the effect of sleeve gastrectomy on impaired sperm parameters, hormonal profile and testis tissue remains controversial to some extent. The context and purpose of the study: Effects of sleeve gastrectomy on hormonal profile, sperm parameters, and testis tissue in infertile men with type II diabetes mellitus (TIIDM). This study included thirty two TIIDM that were scheduled with and without sleeve gastrectomy. All rats were taken a sperm analysis, a testis tissue and a serum hormone profile before, 8 weeks after surgery. Results: There was a significant correlation between weight loss after sleeve gastrectomy and decreased in glucose profile (p < 0.05). As regards the hormonal profile, testosterone improved significantly after 8 weeks following sleeve gastrectomy.There was a significant increase in sperm count (p < 0.05), and improved sperm morphology during the follow-up after sleeve gastrectomy, also showed that significant changes as improved in testis tissue after surgery. Conclusion: Sleeve gastrectomy significantly improves testosterone deficiency, testis tissue and sperm count in TIIDM rats. More prospective clinical studies are needed to show how bariatric surgery affects infertility affected by TIIDM patients.

Keywords:
metabolic intervention, sperm quality, Testosterone, Testis tissue, Type II Diabetes Mellitus(TIIDM), Infertility

Received:
10 Jan 2025;
Accepted:
03 Mar 2025.

Copyright:
© 2025
Tumentemur, Titiz and Bobus Ors. This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) or licensor are credited and that the
original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which
does not comply with these terms.

* Correspondence:
Gamze Tumentemur, Acıbadem University, Istanbul, Türkiye

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