Hypothalamic GABAergic Neurons: Their Roles in Health and Metabolic Diseases
REVIEW article
Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 16 – 2025 |
doi: 10.3389/fendo.2025.1551741
Provisionally accepted
- 1 Southwest Medical University, Luzhou, China
- 2 Peking University, Beijing, Beijing Municipality, China
The final, formatted version of the article will be published soon.
Hypothalamic GABAergic neurons are important in regulating metabolic homeostasis and energy balance. Serving as critical integrators of catabolic and anabolic processes, these neurons orchestrate a broad spectrum of metabolic functions, including feeding, nutrient metabolism, fluid homeostasis, basal metabolism, thermoregulation, and circadian rhythms. Recent advances in neuroscience have facilitated a deeper exploration of the role of hypothalamic GABAergic neurons in metabolic regulation. Emerging research has uncovered key mechanisms through which these neurons modulate energy balance and maintain metabolic balance. These findings not only enhance our understanding of obesity and related metabolic disorders but also underscore the link between hypothalamic dysfunction and prevalent metabolic diseases such as obesity and type 2 diabetes. This review summarizes the latest advancements in our understanding of the role of hypothalamic GABAergic neurons in metabolic regulation. It aims to elucidate the neural and molecular mechanisms underlying hypothalamic control of metabolism, offering new perspectives for the diagnosis and treatment of metabolic disorders.
Keywords:
：Hypothalamus GABAergic neurons, Metabolism regulation, energy balance, Neural projections, neural and molecular mechanisms
Received:
03 Jan 2025;
Accepted:
19 Feb 2025.
Copyright:
© 2025
Wang, YU, Li, Xiong, Zhang, Wan, Zheng and Zhang. This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) or licensor are credited and that the
original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which
does not comply with these terms.
* Correspondence:
Ruimao Zheng, Peking University, Beijing, 100871, Beijing Municipality, China
Chunxiang Zhang, Southwest Medical University, Luzhou, China
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