Intermittent fasting as a treatment for obesity in young people: a scoping review
Obesity and Overweight Available online: (accessed on 20 July 2024).
Koliaki, C., Dalamaga, M. & Liatis, S. Update on the obesity epidemic: after the sudden rise, is the upward trajectory beginning to flatten? Curr. Obes. Rep. 12, 514–527 (2023).
Google Scholar
Ogden, C. L. et al. Differences in obesity prevalence by demographics and urbanization in US children and adolescents, 2013–2016. J. Am. Med. Assoc. 319, 2410–2418 (2018).
Google Scholar
Hales, C. M., Fryar, C. D., Carroll, M. D., Freedman, D. S. & Ogden, C. L. Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007–2008 to 2015–2016. J. Am. Med. Assoc. 319, 1723–1725 (2018).
Google Scholar
Ogden, C. L. et al. Trends in obesity prevalence by race and hispanic origin – 1999-2000 to 2017-2018. J. Am. Med. Assoc. 324, 1208–1210 (2020).
Google Scholar
Hampl, S.E. et al. Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity. Pediatrics, 151 (2023).
Skelton, J. A. & Beech, B. M. Attrition in paediatric weight management: a review of the literature and new directions. Obes. Rev. 12, e273–e281 (2011).
Google Scholar
Skelton, J. A., Irby, M. B., Beech, B. M. & Rhodes, S. D. Attrition and family participation in obesity treatment programs: clinicians’ perceptions. Acad. Pediatr. 12, 420–428 (2012).
Google Scholar
Dhaliwal, J. et al. Attrition and the management of pediatric obesity: an integrative review. Child. Obes. 10, 461–473 (2014).
Google Scholar
Schmied, E. A. et al. Factors predicting parent engagement in a family-based childhood obesity prevention and control program. BMC Public Health 23, 457–457 (2023).
Google Scholar
Kumar, S. et al. Family-based mindful eating intervention in adolescents with obesity: a pilot randomized clinical trial. Children 5, (2018).
Phillips, N. et al. The effects of time-restricted eating versus standard dietary advice on weight, metabolic health and the consumption of processed food: a pragmatic randomised controlled trial in community-based adults. Nutrients 13, 1042 (2021).
Google Scholar
Hart, C. N., Jelalian, E. & Raynor, H. A. Behavioral and social routines and biological rhythms in prevention and treatment of pediatric obesity. Am. Psychol. 75, 152–162 (2020).
Google Scholar
Hart, C. N. et al. Effect of changes in children’s bedtime and sleep period on targeted eating behaviors and timing of caloric intake. Eat. Behav. 45, 101629–101629 (2022).
Google Scholar
Baron, K. G. et al. Circadian timing and alignment in healthy adults: associations with BMI, body fat, caloric intake and physical activity. Int J. Obes. 41, 203–209 (2017).
Google Scholar
Browne, N. T. & Cuda, S. E. Nutritional and activity recommendations for the child with normal weight, overweight, and obesity with consideration of food insecurity: an Obesity Medical Association (OMA) clinical practice statement 2022. Obes. Pillars 2, 100012 (2022).
Google Scholar
Vidmar, A.P. et al. Time Limited Eating in Adolescents with Obesity (Time LEAd): study protocol. Contemp. Clin. Trials 95, (2020).
Zang, B. Y., He, L. X. & Xue, L. Intermittent fasting: potential bridge of obesity and diabetes to health? Nutrients 14, 981 (2022).
Google Scholar
Freire, R. Scientific evidence of diets for weight loss: different macronutrient composition, intermittent fasting, and popular diets. Nutrition 69, 110549–110549 (2020).
Google Scholar
Stockman, M.-C., Thomas, D., Burke, J. & Apovian, C. M. Intermittent fasting: is the wait worth the weight. Curr. Obes. Rep. 7, 172–185 (2018).
Google Scholar
Vidmar, A. P. et al. Integration of time-based recommendations with current pediatric health behavior guidelines: implications for obesity prevention and treatment in youth. Curr. Obes. Rep. 11, 236–253 (2022).
Google Scholar
Chambers, L., Seidler, K. & Barrow, M. Circadian misalignment in obesity: the role for time-restricted feeding. Clin. Nutr. ESPEN 57, 430–447 (2023).
Google Scholar
St-Onge, M.-P. et al. Meal timing and frequency: implications for cardiovascular disease prevention: a scientific statement from the American Heart Association. Circulation 135, e96–e121 (2017).
Google Scholar
Varady, K. A., Cienfuegos, S., Ezpeleta, M. & Gabel, K. Cardiometabolic benefits of intermittent fasting. Annu. Rev. Nutr. 41, 333–361 (2021).
Google Scholar
Gill, S. & Panda, S. A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits. Cell Metab. 22, 789–798 (2015).
Google Scholar
Chow, L. S. et al. Time-restricted eating effects on body composition and metabolic measures in humans who are overweight: a feasibility study. Obesity 28, 860–869 (2020).
Google Scholar
Gabel, K., Hoddy, K. K. & Varady, K. A. Safety of 8-h time-restricted feeding in adults with obesity. Appl. Physiol. Nutr. Metab. 44, 107–109 (2019).
Google Scholar
Gabel, K. et al. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr. Healthy Aging 4, 345–353 (2018).
Google Scholar
Simon, S.L. et al. The impact of a self-selected time-restricted eating intervention on eating patterns, sleep, and late-night eating in individuals with obesity. Front. Nutr. 9, (2022).
Moro, T. et al. Twelve months of time-restricted eating and resistance training improves inflammatory markers and cardiometabolic risk factors. Med. Sci. Sports Exerc. 53, 2577–2585 (2021).
Google Scholar
Schuppelius, B., Peters, B., Ottawa, A., Pivovarova-Ramich, O. Time-restricted eating: a dietary strategy to prevent and treat metabolic disturbances. Front. Endocrinol. 12, (2021).
Chaix, A., Manoogian, E. N. C., Melkani, G. C. & Panda, S. Time-restricted eating to prevent and manage chronic metabolic diseases. Annu. Rev. Nutr. 39, 291–315 (2019).
Google Scholar
Longo, V. D., Di Tano, M., Mattson, M. P. & Guidi, N. Intermittent and periodic fasting, longevity and disease. Nat. Aging 1, 47–59 (2021).
Google Scholar
Jamshed, H. et al. Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans. Nutrients, 11, (2019).
de Cabo, R. & Mattson, M. P. Effects of intermittent fasting on health, aging, and disease. N. Engl. J. Med. 381, 2541–2551 (2019).
Google Scholar
Vidmar, A.P. et al. Time-limited eating and continuous glucose monitoring in adolescents with obesity: a pilot study. Nutrients 13, (2021).
Jebeile, H. et al. Intermittent energy restriction is a feasible, effective, and acceptable intervention to treat adolescents with obesity. J. Nutr. 149, 1189–1197 (2019).
Google Scholar
Pellegrini, M. et al. Correction to: Effects of time-restricted feeding on body weight and metabolism. a systematic review and meta-analysis (Reviews in Endocrine and Metabolic Disorders). Rev. Endocr. Metab. Disord. 21, 35 (2020).
Google Scholar
Pureza, I. R. et al. Effect of early time-restricted feeding on the metabolic profile of adults with excess weight: a systematic review with meta-analysis. Clin. Nutr. 40, 1788–1799 (2021).
Google Scholar
Park, J. et al. Effect of alternate-day fasting on obesity and cardiometabolic risk: a systematic review and meta-analysis. Metabolism 111, (2020).
Roman, Y. M. et al. Effects of intermittent versus continuous dieting on weight and body composition in obese and overweight people: a systematic review and meta-analysis of randomized controlled trials. Int. J. Obes. 43, 2017–2027 (2019).
Google Scholar
Cui, Y. et al. Health effects of alternate-day fasting in adults: a systematic review and meta-analysis. Front. Nutr. 7, (2020).
He, S., Wang, J., Zhang, J. & Xu, J. Intermittent versus continuous energy restriction for weight loss and metabolic improvement: a meta-analysis and systematic review. Obesity 29, 108–115 (2021).
Google Scholar
Meng, H. et al. Effects of intermittent fasting and energy-restricted diets on lipid profile: a systematic review and meta-analysis. Nutrition 77, (2020).
Cho, Y. et al. The effectiveness of intermittent fasting to reduce body mass index and glucose metabolism: a systematic review and meta-analysis. J. Clin. Med. 8, (2019).
Patikorn, C. et al. Intermittent fasting and obesity-related health outcomes: an umbrella review of meta-analyses of randomized clinical trials. JAMA Netw. Open 4, (2021).
Alorfi, N. M. & Ashour, A. M. The impact of intermittent fasting on non-alcoholic fatty liver disease in older adults: a review of clinicaltrials.Gov registry. Diab., Metab. Syndr. Obes. 16, 3115–3121 (2023).
Google Scholar
Pieczyńska-Zając, J.M., Malinowska, A., Łagowska, K., Leciejewska, N., Bajerska, J. The effects of time-restricted eating and Ramadan fasting on gut microbiota composition: a systematic review of human and animal studies. Nutr. Rev. (2023).
Cheng, W.Y., Desmet, L., Depoortere, I. Time-restricted eating for chrono disruption-related chronic diseases. Acta Physiol. 239, (2023).
Sharma, S. K. et al. Effect of intermittent fasting on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. touchREV. Endocrinol. 19, 25–32 (2023).
Google Scholar
Barati, M., Ghahremani, A. & Namdar Ahmadabad, H. Intermittent fasting: a promising dietary intervention for autoimmune diseases. Autoimmun. Rev. 22, (2023).
Elsworth, R.L. et al. The effect of intermittent fasting on appetite: a systematic review and meta-analysis. Nutrients 15, (2023).
Lange, M. et al. Intermittent fasting improves hepatic end points in nonalcoholic fatty liver disease: a systematic review and meta-analysis. Hepatol. Commun. 7, (2023).
Silva, A.I., Direito, M., Pinto-Ribeiro, F., Ludovico, P. & Sampaio-Marques, B. Effects of intermittent fasting on regulation of metabolic homeostasis: a systematic review and meta-analysis in health and metabolic-related disorders. J. Clin. Med. 12, (2023).
Popa, A.D. et al. A scoping review of the relationship between intermittent fasting and the human gut microbiota: current knowledge and future directions. Nutrients 15, (2023).
Shabkhizan, R. et al. The beneficial and adverse effects of autophagic response to caloric restriction and fasting. Adv. Nutr. 14, 1211–1225 (2023).
Google Scholar
Lange, M. G. et al. Metabolic changes with intermittent fasting. J. Hum. Nutr. Diet. 37, 256–269 (2024).
Google Scholar
Jaramillo, A. P. et al. Time-restricted feeding and intermittent fasting as preventive therapeutics: a systematic review of the literature. Cureus 15, e42300 (2023).
Google Scholar
Küçük, A. N. & Çiftçi, S. The role of intermittent fasting and the ketogenic diet in cancer disease: can they replace the Mediterranean diet? Eur. J. Cancer Prev. 32, 533–543 (2023).
Google Scholar
Psara, E. et al. Intermittent fasting against cancer development and progression: highlighting potential anticancer molecular mechanisms. Anticancer Agents Med. Chem. 23, 1889–1909 (2023).
Google Scholar
Herz, D. et al. Efficacy of fasting in type 1 and type 2 diabetes mellitus: a narrative review. Nutrients 15, (2023).
Kamarul Zaman, M., Teng, N. I. M. F., Kasim, S. S., Juliana, N. & Alshawsh, M. A. Effects of time-restricted eating with different eating duration on anthropometrics and cardiometabolic health: a systematic review and meta-analysis. World J. Cardiol. 15, 354–374 (2023).
Google Scholar
Roy, Y.J., Lyutakov, I. The effect of Ramadan and intermittent fasting on the development of helicobacter pylori-induced peptic ulcers. Br. J. Hosp. Med. 84, (2023).
Naous, E., Achkar, A., Mitri, J. Intermittent fasting and its effects on weight, glycemia, lipids, and blood pressure: a narrative review. Nutrients 15, (2023).
Wang, C., Liu, Z., Cai, J., Xu, X. The regulatory effect of intermittent fasting on inflammasome activation in health and disease. Nutr. Rev. (2023).
Ye, Y.C. et al. Intermittent fasting and Alzheimer’s disease—targeting ketone bodies as a potential strategy for brain energy rescue. Metab. Brain Dis. (2023).
Santos, H.O. Intermittent fasting in the management of diabetes: a review of glycemic control and safety. Nutr. Rev. (2023).
Nie, Z. et al. Effects of time-restricted eating with different eating windows on human metabolic health: pooled analysis of existing cohorts. Diabetol. Metab. Syndr. 15, 209 (2023).
Google Scholar
Mishra, A., Sobha, D., Patel, D., Suresh, P.S. Intermittent fasting in health and disease. Arch. Physiol. Biochem. 1–13, (2023).
Murta, L., Seixas, D., Harada, L., Damiano, R.F., Zanetti, M. Intermittent fasting as a potential therapeutic instrument for major depression disorder: a systematic review of clinical and preclinical studies. Int. J. Mol. Sci. 24, (2023).
Al Zein, M. et al. Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis. Biochem. Pharmacol. 218, (2023).
Schroor, M.M., Joris, P.J., Plat, J. & Mensink, R.P. Effects of intermittent energy restriction compared with those of continuous energy restriction on body composition and cardiometabolic risk markers—a systematic review and meta-analysis of randomized controlled trials in adults. Adv. Nutr. (2023).
Guo, M. et al. Intermittent fasting on neurologic diseases: potential role of gut microbiota. Nutrients 15, (2023).
Kazeminasab, F. et al. Effects of intermittent fasting combined with physical exercise on cardiometabolic outcomes: systematic review and meta-analysis of clinical studies. Nutr. Rev. (2023).
Ma, Y., Sun, L. & Mu, Z. Network meta-analysis of three different forms of intermittent energy restrictions for overweight or obese adults. Int J. Obes. 48, 55–64 (2024).
Google Scholar
Rovira-Llopis, S. et al. Circadian alignment of food intake and glycaemic control by time-restricted eating: a systematic review and meta-analysis. Rev. Endocr. Metab. Disord. (2023).
Khalafi, M. et al. Combined versus independent effects of exercise training and intermittent fasting on body composition and cardiometabolic health in adults: a systematic review and meta-analysis. Nutr. J. 23, 7 (2024).
Google Scholar
Ezpeleta, M. et al. Time-restricted eating: watching the clock to treat obesity. Cell Metab. (2023).
Conde-Pipó, J. et al. Intermittent fasting: does it affect sports performance? A systematic review. Nutrients 16, (2024).
Saleh, S. A. K. et al. Effects of intermittent fasting regimens on glycemic, hepatic, anthropometric, and clinical markers in patients with non-alcoholic fatty liver disease: systematic review and meta-analysis of randomized controlled trials. Clin. Nutr. ESPEN 59, 70–80 (2024).
Google Scholar
O’Leary, J., Georgeaux-Healy, C., Serpell, L. The impact of continuous calorie restriction and fasting on cognition in adults without eating disorders. Nutr. Rev. (2024).
Yao, K. et al. Effectiveness of an intermittent fasting diet versus regular diet on fat loss in overweight and obese middle-aged and olderly people without metabolic disease: a systematic review and meta-analysis of randomized controlled trials. J. Nutr. Health Aging, 28, (2024).
James, D.L. et al. Impact of intermittent fasting and/or caloric restriction on aging-related outcomes in adults: a scoping review of randomized controlled trials. Nutrients 16, (2024).
Alkurd, R. et al. Effect of calorie restriction and intermittent fasting regimens on brain-derived neurotrophic factor levels and cognitive function in humans: a systematic review. Medicina 60, (2024).
Hourizadeh, J., Munshi, R., Zeltser, R. & Makaryus, A. Dietary effects of fasting on the lipid panel. Curr. Cardiol. Rev. 20, (2024).
Lin, X., Wang, S. & Gao, Y. The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review. Front. Nutr. 10, 1328426 (2023).
Google Scholar
Xiaoyu, W., Yuxin, X. & Li, L. The effects of different intermittent fasting regimens in people with type 2 diabetes: a network meta-analysis. Front. Nutr. 11, 1325894 (2024).
Google Scholar
Varady, K.A., Runchey, M.-C., Reutrakul, S., Vidmar, A.P. & Chow, L.S. Clinical potential of fasting in type 1 diabetes. Trends Endocrinol. Metab. (2024).
Castillo, M.F., Salgado-Canales, D., Arrese, M., Barrera, F. & Mikhailidis, D.P. Effect of intermittent fasting on lipid profile, anthropometric and hepatic markers in Non-Alcoholic Fatty Liver Disease (NAFLD): a systematic review. Curr. Vasc. Pharmacol. 22, (2024).
Moon, S. et al. Beneficial effects of time-restricted eating on metabolic diseases: a systemic review and meta-analysis. Nutrients 12, 1267, (2020).
Google Scholar
Tricco, A. C. et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann. Intern. Med. 169, 467, (2018).
Google Scholar
Liberati, A. et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339, b2700–b2700 (2009).
Google Scholar
Dos Santos, W. M., Secoli, S. R., Püschel, V. A. & de, A. The Joanna Briggs Institute approach for systematic reviews. Rev. Lat. Am. Enferm. 26, e3074–e3074, (2018).
Google Scholar
Campbell, M. et al. Synthesis without Meta-Analysis (SWiM) in systematic reviews: reporting guideline. BMJ 368, (2020).
Sekhon, M., Cartwright, M. & Francis, J. J. Development of a theory-informed questionnaire to assess the acceptability of healthcare interventions. BMC Health Serv. Res. 22, 1–12 (2022).
Google Scholar
O’Connor, K. L. et al. Altered appetite-mediating hormone concentrations precede compensatory overeating after severe, short-term energy deprivation in healthy adults. J. Nutr. 146, 209–217 (2016).
Google Scholar
Hegedus, E. et al. Randomized controlled feasibility trial of late 8-hour time-restricted eating for adolescents with type 2 diabetes. J. Acad. Nutr. Diet, (2023).
Smith, S.T., LeSarge, J.C. & Lemon, P.W.R. Time-restricted eating in women—a pilot study. Western Undergrad. Res. J. Health Nat. Sci. 8, (2017).
Tinsley, G. M. et al. Time-restricted feeding in young men performing resistance training: a randomized controlled trial. Eur. J. Sport Sci. 17, 200–207 (2017).
Google Scholar
Tinsley, G. M. et al. Time-restricted feeding plus resistance training in active females: a randomized trial. Am. J. Clin. Nutr. 110, 628–640 (2019).
Google Scholar
Zeb, F. et al. Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males. Br. J. Nutr. 123, 1216–1226 (2020).
Google Scholar
Park, S.-J., Yang, J.-W. & Song, Y.-J. The effect of four weeks dietary intervention with 8-hour time-restricted eating on body composition and cardiometabolic risk factors in young adults. Nutrients 13, 2164 (2021).
Google Scholar
Zhang, L. et al. Randomized controlled trial for time-restricted eating in overweight and obese young adults. iScience 25, 104870–104870 (2022).
Google Scholar
McAllister, M. J., Pigg, B. L., Renteria, L. I. & Waldman, H. S. Time-restricted feeding improves markers of cardiometabolic health in physically active college-age men: a 4-week randomized pre-post pilot study. Nutr. Res. 75, 32–43 (2020).
Google Scholar
Moro, T. et al. Time-restricted eating effects on performance, immune function, and body composition in elite cyclists: a randomized controlled trial. J. Int. Soc. Sports Nutr. 17 (2020).
Wegman, M. P. et al. Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. Rejuven. Res. 18, 162–172 (2015).
Google Scholar
Bao, R. et al. Effects of time-restricted feeding on energy balance: a cross-over trial in healthy subjects. Front Endocrinol. 13, 870054–870054 (2022).
Google Scholar
Correia, J.M. et al. Effects of time-restricted feeding on supramaximal exercise performance and body composition: a randomized and counterbalanced crossover study in healthy men. Int. J. Environ. Res. Public Health, 18, (2021).
Clayton, D. J. et al. 24-h severe energy restriction impairs postprandial glycaemic control in young, lean males. Br. J. Nutr. 120, 1107–1116, (2018).
Google Scholar
Liu, H., Chen, S., Ji, H. & Dai, Z. Effects of time-restricted feeding and walking exercise on the physical health of female college students with hidden obesity: a randomized trial. Front. Public Health 11, (2023).
Kim, J. & Song, Y. Early time-restricted eating reduces weight and improves glycemic response in young adults: a pre-post single-arm intervention study. Obes. Facts 16, 69–81 (2023).
Google Scholar
Stratton, M. T. et al. Four weeks of time-restricted feeding combined with resistance training does not differentially influence measures of body composition, muscle performance, resting energy expenditure, and blood biomarkers. Nutrients 12, 1126 (2020).
Google Scholar
Harder-Lauridsen, N. M. et al. The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial. J. Appl. Physiol. 122, 230–241 (2017).
Google Scholar
Eneli, I. et al. Using a revised protein-sparing modified fast (RPSMF) for children and adolescents with severe obesity: a pilot study. Int J. Environ. Res Public Health 16, 3061 (2019).
Google Scholar
Dannecker, E. A. et al. The effect of fasting on indicators of muscle damage. Exp. Gerontol. 48, 1101–1106 (2013).
Google Scholar
Atkinson, F. S., Heruc, G. A., Tan, V. M. H., Petocz, P. & Brand-Miller, J. C. Extending the overnight fast: sex differences in acute metabolic responses to breakfast. Nutrients 12, 1–10 (2020).
Google Scholar
Thivel, D. et al. Energy depletion by 24-h fast leads to compensatory appetite responses compared with matched energy depletion by exercise in healthy young males. Br. J. Nutr. 120, 583–592 (2018).
Google Scholar
Stocks, B., Dent, J. R., Ogden, H. B., Zemp, M. & Philp, A. Postexercise skeletal muscle signaling responses to moderate- to high-intensity steady-state exercise in the fed or fasted state. Am. J. Physiol. Endocrinol. Metab. 316, E230–E238 (2019).
Google Scholar
Naharudin, M. N., Bin & Yusof, A. The effect of 10 days of intermittent fasting on Wingate anaerobic power and prolonged high-intensity time-to-exhaustion cycling performance. Eur. J. Sport Sci. 18, 667–676 (2018).
Google Scholar
McIver, V. J., Mattin, L. R., Evans, G. H. & Yau, A. M. W. Diurnal influences of fasted and non-fasted brisk walking on gastric emptying rate, metabolic responses, and appetite in healthy males. Appetite 143, 104411–104411 (2019).
Google Scholar
Lister, N.B. et al. Intermittent energy restriction for adolescents with obesity. JAMA Pediatr. (2024).
Tucker, J.M. et al. Acceptability of time-limited eating in pediatric weight management. Front. Endocrinol. 13, (2022).
de Souza, M. R. et al. Skipping breakfast is associated with the presence of cardiometabolic risk factors in adolescents: study of cardiovascular risks in adolescents—ERICA. Br. J. Nutr. 126, 276–284 (2021).
Google Scholar
Dote-Montero, M. et al. Association of meal timing with body composition and cardiometabolic risk factors in young adults. Eur. J. Nutr. 62, 2303–2315 (2023).
Google Scholar
Zerón-Rugerio, M.F. et al. The elapsed time between dinner and the midpoint of sleep is associated with adiposity in young women. (2020).
McHill, A. W. et al. Later circadian timing of food intake is associated with increased body fat. Am. J. Clin. Nutr. 106, 1213–1219 (2017).
Google Scholar
Colombarolli, M. S., de Oliveira, J. & Cordás, T. A. Craving for carbs: food craving and disordered eating in low-carb dieters and its association with intermittent fasting. Eat. Weight Disord. 27, 3109–3117 (2022).
Google Scholar
Bowen, D. J. et al. How we design feasibility studies. Am. J. Prev. Med. 36, 452–457 (2009).
Google Scholar
Orsmond, G.I. & Cohn, E.S. The distinctive features of a feasibility study. Occup. Ther. J. Res. 35, 169–177, (2015).
Cienfuegos, S. et al. Effects of 4- and 6-h time-restricted feeding on weight and cardiometabolic health: a randomized controlled trial in adults with obesity. Cell Metab. 32, 366–378.e3 (2020).
Google Scholar
Duncanson, K. et al. Impact of weight management nutrition interventions on dietary outcomes in children and adolescents with overweight or obesity: a systematic review with meta-analysis. J. Hum. Nutr. Diet. 34, 147–177 (2021).
Google Scholar
Adeola, O.L. et al. The effectiveness of nutritional strategies in the treatment and management of obesity: a systematic review. Cureus 15, (2023).
Andela, S. et al. Efficacy of very low-energy diet programs for weight loss: a systematic review with meta-analysis of intervention studies in children and adolescents with obesity. Obes. Rev. 20, 871–882 (2019).
Google Scholar
Li, Z., Huang, L., Luo, Y., Yu, B. & Tian, G. Effects and possible mechanisms of intermittent fasting on health and disease: a narrative review. Nutr. Rev. 81, 1626–1635 (2023).
Google Scholar
Xiao, Q., Garaulet, M. & Scheer, F. A. J. L. Meal timing and obesity: interactions with macronutrient intake and chronotype. Int. J. Obes. 43, 1701–1711 (2019).
Google Scholar
Ali, M., Reutrakul, S., Petersen, G. & Knutson, K. L. Associations between timing and duration of eating and glucose metabolism: a nationally representative study in the U.S. Nutrients 15, 729 (2023).
Google Scholar
Vidmar, A.P., Wee, C.P., Salvy, S.-J., Bakhsh, J.A. & Goran, M.I. Timing of meal consumption on glucose profiles in Latino adolescents with obesity. Horm. Res. Paediatr. 1–1, (2024).
Paul, L. Diet, nutrition and telomere length. J. Nutr. Biochem. 22, 895–901 (2011).
Google Scholar
Galiè, S. et al. Impact of nutrition on telomere health: systematic review of observational cohort studies and randomized clinical trials. Adv. Nutr. 11, 576–601 (2020).
Google Scholar
Dietary Guidelines for Americans, 2020–2025 Available online: (accessed on 15 July 2023).
Vanderwall, C. & Carrel, A. L. Response to “Intermittent energy restriction is a feasible, effective, and acceptable intervention to treat adolescents with obesity” by H Jebeile et al. J. Nutr. 150, 1337–1338 (2020).
Google Scholar
Jebeile, H. et al. Treatment of obesity, with a dietary component, and eating disorder risk in children and adolescents: a systematic review with meta‐analysis. Obes. Rev. 20, 1287 (2019).
Google Scholar
Jebeile, H. et al. Symptoms of depression, eating disorders, and binge eating in adolescents with obesity. JAMA Pediatr. (2024).
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