Association Between Thyroid Hormone Sensitivity and Carotid Plaque Risk: A Health Examination Cohort-based Study

ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Thyroid Endocrinology

Volume 15 – 2024 |
doi: 10.3389/fendo.2024.1472752

Provisionally accepted

¹
Health Management Center, Union Hospital ,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²
Department of Breast and Thyroid Surgery, Union Hospital ,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

The final, formatted version of the article will be published soon.

Introduction: The involvement of thyroid hormone in cardiovascular disease remains debated. The aim of our research was to ascertain whether thyroid hormone sensitivity indices are related to carotid plaque (CAP) risk in the general population. Methods: We recruited 5,360 participants for health examinations to explore the correlation between thyroid hormone sensitivity indices and CAP risk. We then compared baseline characteristics of participants with CAP to those without CAP based on multivariate logistic regression analysis. Additionally, we conducted subgroup analyses stratified by gender and age to further elucidate this relationship. Results: Among the 5,360 participants, 1,055 (19.7%) were diagnosed with CAP. After adjusting for various confounding factors, our results showed a positive association between CAP risk and the indices (TFQI, PTFQI, TSHI, and TT4RI). Conversely, the FT3/FT4 ratio showed a negative correlation with CAP risk. Sex-based subgroup analysis revealed a stronger correlation between thyroid hormone sensitivity and CAP in females compared to males. In the age subgroup, the significant association was observed in older individuals (age >60) compared to middle-aged participants (age ≤60). Conclusion: Our study suggests a significant correlation between thyroid hormone sensitivity and CAP, particularly in females and participants over the age of 60.

Keywords:
carotid plaque1, thyroid hormone sensitivity2, health examination3, Logistic regression4, subgroup analysis5

Received:
30 Jul 2024;
Accepted:
19 Nov 2024.

Copyright:
© 2024 Gong, Wang, Ding, Yu, Xu, Xu and Ling. This is an
open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) or licensor are credited and that the
original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which
does not comply with these terms.

* Correspondence:
Yan Ling, Health Management Center, Union Hospital ,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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